Description

2-Chloro-5-Fluoro-3-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring chlorine, fluorine, and a trifluoromethyl group, provides exceptional reactivity and physicochemical properties for creating complex molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries seeking to introduce specific halogenated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups contribute to improved efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for functionalized ligands, liquid crystals, and advanced polymers requiring specific electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive chlorine atom.
• Fluorinated Compound Research: A valuable reagent in medicinal and agrochemical research for studying structure-activity relationships (SAR) of fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Chloro-5-Fluoro-3-(Trifluoromethyl)Pyridine
CAS No.	72587-20-3
Molecular Formula	C6H2ClF4N
Molecular Weight	199.53 g/mol
Synonyms	2-Chloro-5-fluoro-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoro-alpha,alpha,α-trifluoro-3-picoline; 72587-20-3; Pyridine, 2-chloro-5-fluoro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-3-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS and NMR for identity and impurity profiling, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended long-term storage at controlled room temperature (15-25°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.