Description

2-Chloro-5-(trifluoromethyl)-3-pyridinamine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining chlorine and trifluoromethyl substituents, provides exceptional reactivity and physicochemical properties for creating complex molecules. This intermediate is essential for researchers and manufacturers in the agrochemical and pharmaceutical sectors developing novel active ingredients.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for constructing drug candidates, particularly in molecules targeting central nervous system and metabolic diseases.
• Material Science Research: Employed in the development of specialty chemicals, liquid crystals, and functional polymers requiring specific halogenated aromatic units.
• Cross-Coupling Reactions: Serves as a versatile substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to form complex biaryl structures.

Basic Information

Product Name	2-Chloro-5-(trifluoromethyl)-3-pyridinamine
CAS No.	72587-18-9
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	3-Amino-2-chloro-5-(trifluoromethyl)pyridine; 2-Chloro-5-(trifluoromethyl)pyridin-3-amine; 2-Chloro-5-trifluoromethyl-3-aminopyridine; 72587-18-9; 2-Chloro-α,α,α-trifluoro-3-pyridinamine; 3-Pyridinamine, 2-chloro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(trifluoromethyl)-3-pyridinamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and identity confirmation. Our quality commitment aligns with cGMP principles for advanced intermediates, supporting our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.