Description

5-Amino-6-Chloronicotinic Acid is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. Its unique molecular structure, featuring both amino and chloro substituents on the pyridine ring, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its chloronicotinic acid backbone.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.
• Academic and R&D Laboratories: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	5-Amino-6-Chloronicotinic Acid
CAS No.	72587-17-8
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	6-Chloro-5-aminonicotinic Acid; 5-Amino-6-chloropyridine-3-carboxylic Acid; 3-Carboxy-2-chloro-5-aminopyridine; 2-Chloro-5-amino-3-pyridinecarboxylic Acid; 72587-17-8; 5-Amino-6-chloro-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-6-Chloronicotinic Acid is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.