Description

Methyl 3-Bromo-2-Fluoro-5-Methylbenzoate is a high-purity, multi-functional halogenated benzoate ester, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular architecture, which provides versatile reactivity for constructing complex pharmacophores and agrochemical active ingredients. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the bromo and fluoro substituents enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organocatalysts.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and liquid crystals, where halogenated aromatics tune electronic properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Methyl 3-Bromo-2-Fluoro-5-Methylbenzoate
CAS No.	72518-21-9
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	3-Bromo-2-fluoro-5-methylbenzoic acid methyl ester; Methyl 3-bromo-2-fluoro-5-methylbenzoate; Benzoic acid, 3-bromo-2-fluoro-5-methyl-, methyl ester; 2-Fluoro-3-bromo-5-methylbenzoic acid methyl ester; 72518-21-9; Methyl 3-bromo-2-fluoro-p-toluate
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-Bromo-2-Fluoro-5-Methylbenzoate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.