Description

3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,3-Methyl-,Methylester,(1-α-,2-α-,5-α-)-(9Ci) is a high-purity, synthetically valuable bicyclic proline derivative, serving as a critical chiral building block in advanced organic synthesis. Its constrained, rigid scaffold is essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, neurological agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides with enhanced biological activity and selectivity.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands or catalysts in stereoselective synthesis.
• Peptidomimetics & Constrained Peptide Design: Its fused bicyclic structure is ideal for introducing conformational rigidity into peptide backbones to improve stability and bioavailability.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Material Science: Potential use as a monomer or building block for specialty polymers with unique structural properties.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,3-Methyl-,Methylester,(1-α-,2-α-,5-α-)-(9Ci)
CAS No.	72496-50-5
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	Methyl 3-methyl-3-azabicyclo[3.1.0]hexane-2-carboxylate; (1R,2R,5S)-Methyl 3-methyl-3-azabicyclo[3.1.0]hexane-2-carboxylate; 3-Methyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester; Bicyclic proline methyl ester derivative; (1α,2α,5α)-3-Methyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,3-Methyl-,Methylester,(1-α-,2-α-,5-α-)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.