Description

3-Butynyl Methanesulfonate is a versatile alkyne-containing methanesulfonate ester, a key building block in advanced organic synthesis. Its reactive terminal alkyne and excellent leaving group make it a critical intermediate for constructing complex molecular architectures through cross-coupling and click chemistry reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing alkyne functional handles for further derivatization via Sonogashira or Huisgen cycloaddition reactions.
• Agrochemical Synthesis: Serves as a key precursor in creating novel herbicides, fungicides, and plant growth regulators that require alkyne motifs for bioactivity.
• Material Science & Polymer Chemistry: Employed as a monomer or cross-linking agent in the production of specialty polymers, dendrimers, and functional surfaces with tailored properties.
• Bioconjugation & Probe Development: Acts as a linker for attaching fluorescent dyes, affinity tags, or other reporter molecules to biomolecules in diagnostic and research applications.
• Organic Synthesis Building Block: Facilitates carbon-carbon bond formation in complex natural product synthesis and medicinal chemistry campaigns, enabling rapid scaffold diversification.
• Ligand & Catalyst Preparation: Used to synthesize novel phosphine or N-heterocyclic carbene ligands containing alkyne groups for transition metal catalysis.

Basic Information

Product Name	3-Butynyl Methanesulfonate
CAS No.	72486-09-0
Molecular Formula	C5H8O3S
Molecular Weight	148.18 g/mol
Synonyms	But-3-yn-1-yl methanesulfonate; 3-Butyn-1-yl methanesulfonate; Methanesulfonic acid 3-butynyl ester; 3-Butynyl mesylate; 4-Butynyl methanesulfonate (common misnomer); 3-Butyn-1-yl mesylate; But-3-ynyl methanesulfonate
EINECS	Contact for details

Quality Control

Our 3-Butynyl Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.