Description

2,2-Dimethylpropylisocyanide is a specialized organic building block featuring a reactive isocyanide functional group attached to a neopentyl (2,2-dimethylpropyl) backbone. This compound is valued for its role as a versatile reagent in multi-component reactions and transition metal-catalyzed transformations, enabling the efficient synthesis of complex heterocycles and natural product analogs. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the Passerini and Ugi multi-component reactions for the rapid generation of diverse compound libraries and peptidomimetics.
• Agrochemical Research: Used in the synthesis of novel active ingredients and fungicides with complex heterocyclic cores.
• Ligand Synthesis: Serves as a precursor for the preparation of specialized isocyanide ligands used in organometallic catalysis.
• Material Science: Employed in the development of functional polymers and smart materials via isocyanide-based polymerization.
• Chemical Biology: Utilized in bio-conjugation and probe development due to its selective reactivity.

Basic Information

Product Name	2,2-Dimethylpropylisocyanide
CAS No.	72443-18-6
Molecular Formula	C6H11N
Molecular Weight	97.16 g/mol
Synonyms	Neopentyl isocyanide; (2,2-Dimethylpropyl)isocyanide; 2,2-Dimethylpropaneisocyanide; Isocyano-2,2-dimethylpropane; 1-Isocyano-2,2-dimethylpropane; Tert-butylmethyl isocyanide
EINECS	Contact for details

Quality Control

Our 2,2-Dimethylpropylisocyanide is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, GC, and HPLC analysis, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, assay, and impurity profiles. We adhere to cGMP principles for research-grade chemicals to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its highly volatile nature, ensure containers are securely sealed and handled in a fume hood. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.