Description

1'-Benzyl-Spiro[Benzofuran-3,4'-Piperidine] is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 72374-35-7. This compound is valued for its complex spirocyclic and benzofuran-fused piperidine structure, which serves as a critical building block in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in drug discovery programs targeting various disease pathways.
• CNS Drug Development: Employed in the synthesis of potential neuroactive compounds due to its piperidine moiety, which is common in neuromodulators.
• Oncological Research: Serves as a building block for novel small-molecule candidates in cancer therapy research.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target validation.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.

Basic Information

Product Name	1'-Benzyl-Spiro[Benzofuran-3,4'-Piperidine]
CAS No.	72374-35-7
Molecular Formula	C20H21NO
Molecular Weight	291.39 g/mol
Synonyms	Spiro[benzofuran-3,4'-piperidine], 1'-benzyl-; 1'-Benzylspiro[benzofuran-3,4'-piperidine]; 1-Benzyl-1,4-dihydrospiro[benzofuran-3,4'-piperidine]; 72374-35-7; 1'-Benzyl-1,4-dihydrospiro[benzofuran-3,4'-piperidine]; Benzylspiro(benzofuran-3,4'-piperidine); 1'-Benzylspiro[benzofuran-3,4'-piperidine]
EINECS	Contact for details

Quality Control

Our 1'-Benzyl-Spiro[Benzofuran-3,4'-Piperidine] is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.