Description

n-Acetyl-D-Isoleucine Trimethylsilyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis and pharmaceutical research. This compound is a critical building block for the preparation of peptides and other bioactive molecules, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in proteomics, medicinal chemistry, and the synthesis of complex chiral intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS) to construct specific peptide sequences.
• Proteomics Research: Serves as a standard or reagent in mass spectrometry and analytical studies for amino acid and peptide analysis.
• Bioconjugation Chemistry: Acts as a precursor for creating modified amino acids used in labeling and cross-linking biomolecules.
• Asymmetric Synthesis: Employed in the synthesis of non-proteinogenic amino acids and other complex chiral compounds requiring the D-isoleucine configuration.
• Chemical Reference Standard: Provides a high-purity standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	n-Acetyl-D-Isoleucine Trimethylsilyl Ester
CAS No.	72361-03-6
Molecular Formula	C13H27NO3Si
Molecular Weight	273.45 g/mol
Synonyms	D-Isoleucine, N-acetyl-, trimethylsilyl ester; Ac-D-Ile-OTMS; N-Acetyl-D-isoleucine trimethylsilyl ester; N-Acetyl-D-isoleucine TMS ester; (2R,3R)-2-Acetamido-3-methylpentanoic acid trimethylsilyl ester; Trimethylsilyl N-acetyl-D-isoleucinate; N-Acetyl-O-trimethylsilyl-D-isoleucine
EINECS	Contact for details

Quality Control

Our n-Acetyl-D-Isoleucine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% de (D-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.