Description

Methyl 3-(Dimethylamino)-2-Isocyanoacrylate is a versatile and highly reactive isocyanide building block used in multi-component reactions. This compound is valued for its role in facilitating the efficient synthesis of complex heterocyclic scaffolds and functionalized molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular libraries and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of heterocyclic compounds, including imidazoles, oxazoles, and pyrroles, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used to build novel pesticidal and herbicidal agents through efficient multi-component reaction (MCR) pathways like the Ugi and Passerini reactions.
• Fine Chemical Synthesis: Enables the construction of complex, functionalized molecules for specialty chemicals, dyes, and ligands for catalysis.
• Combinatorial Chemistry: An essential building block for generating diverse compound libraries in drug discovery and material science research.
• Academic & R&D: Employed in methodological development for new organic transformations and as a teaching tool for advanced synthetic chemistry.

Basic Information

Product Name	Methyl 3-(Dimethylamino)-2-Isocyanoacrylate
CAS No.	72130-98-4
Molecular Formula	C8H12N2O2
Molecular Weight	168.19 g/mol
Synonyms	Methyl 2-Isocyano-3-(dimethylamino)acrylate; Methyl (Dimethylamino)(isocyano)acetate; 2-Isocyano-3-(dimethylamino)acrylic Acid Methyl Ester; Methyl α-Isocyano-β-(dimethylamino)acrylate; Isocyanoacetic Acid, (Dimethylamino)methylene Methyl Ester; NSC 163045; Dimethylamino(isocyano)acetic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 3-(Dimethylamino)-2-Isocyanoacrylate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.