Description

(Z)-3-Dimethylamino-2-Isocyano-Acrylic Acid Ethyl Ester is a versatile and highly reactive isocyanide building block used in multicomponent reactions. This compound is valued for its role in the efficient synthesis of complex heterocyclic scaffolds and functionalized molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for lead discovery and optimization.

Application

• Pharmaceutical Intermediates: A key synthon in the synthesis of heterocyclic compounds like imidazoles, oxazoles, and pyrroles, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used to construct novel pesticidal and herbicidal agents through multicomponent reaction (MCR) chemistry, such as Passerini and Ugi reactions.
• Combinatorial Chemistry: Enables the rapid generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Material Science Precursors: Serves as a building block for functionalized polymers and organic electronic materials with tailored properties.
• Academic & R&D: A critical reagent for methodological development in organic synthesis and exploring new reaction pathways in medicinal chemistry.

Basic Information

Product Name	(Z)-3-Dimethylamino-2-Isocyano-Acrylic Acid Ethyl Ester
CAS No.	72130-97-3
Molecular Formula	C9H14N2O2
Molecular Weight	182.22 g/mol
Synonyms	Ethyl (Z)-3-(Dimethylamino)-2-isocyanoacrylate; 2-Isocyano-3-(dimethylamino)acrylic Acid Ethyl Ester; Ethyl 3-(Dimethylamino)-2-isocyano-2-propenoate; NSC 334365; Dimethylamino(isocyano)acrylic Acid Ethyl Ester; (Z)-Ethyl 3-(dimethylamino)-2-isocyanoacrylate
EINECS	Contact for details

Quality Control

Every batch of (Z)-3-Dimethylamino-2-Isocyano-Acrylic Acid Ethyl Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure consistency and purity for your critical synthetic applications. Certificates of Analysis (COA) with detailed specifications from HPLC, NMR, and GC-MS are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.