Description

(1R)-5-(Methoxyimino)-3α-[(Trimethylsilyl)Oxy]-2β-[(1E,3S)-3-(Trimethylsilyloxy)-1-Octenyl]-1α-Cyclopentanepropionic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex, functionalized cyclopentane core. This compound is a critical building block in the synthesis of prostaglandin analogs and other bioactive molecules, offering precise stereochemical control for demanding research and production processes. It is essential for pharmaceutical R&D, process chemistry, and the manufacture of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.

Application

• Key Intermediate in Prostaglandin Synthesis: Serves as a pivotal chiral precursor for the production of prostaglandin and prostacyclin analogs.
• Pharmaceutical R&D: Used in medicinal chemistry for the discovery and development of new drug candidates with anti-inflammatory, cardiovascular, or ocular activity.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing of complex target molecules.
• Synthesis of Bioactive Molecules: A versatile synthon for constructing molecules with specific stereochemistry for biological evaluation.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in API production.

Basic Information

Item	Details
Product Name	(1R)-5-(Methoxyimino)-3α-[(Trimethylsilyl)Oxy]-2β-[(1E,3S)-3-(Trimethylsilyloxy)-1-Octenyl]-1α-Cyclopentanepropionic Acid Methyl Ester
CAS No.	72121-38-1
Molecular Formula	C26H47NO6Si2
Molecular Weight	525.83 g/mol
Synonyms	Methyl (1R,2β,3α,5Z)-5-[(Methoxyimino)]-3-[(trimethylsilyl)oxy]-2-[(1E,3S)-3-(trimethylsilyloxy)-1-octen-1-yl]cyclopentanepropanoate; Prostaglandin Intermediate 72121-38-1; 5-Methoxyimino PGI2 Intermediate; (1R,2β,3α,5Z)-5-[(Methoxyimino)]-3-[(trimethylsilyl)oxy]-2-[(1E,3S)-3-(trimethylsilyloxy)-1-octenyl]cyclopentanepropionic Acid Methyl Ester; TMS-protected Prostaglandin Synthon
EINECS	Contact for details

Quality Control

Our (1R)-5-(Methoxyimino)-3α-[(Trimethylsilyl)Oxy]-2β-[(1E,3S)-3-(Trimethylsilyloxy)-1-Octenyl]-1α-Cyclopentanepropionic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical and chiral purity suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.