Description

3β,11β,21-Trihydroxy-20-Oxo-5α-Pregnan-18-Oic Acid 18,11-Lactone is a high-purity steroid derivative and a key synthetic intermediate in advanced pharmaceutical research. This compound is critical for the development of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex steroid-based molecules, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of specialized corticosteroid analogs and other bioactive steroid compounds.
• Research & Development: Used in academic and industrial laboratories for investigating steroid metabolism, receptor binding studies, and structure-activity relationship (SAR) research.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scaling up synthetic routes for potential active pharmaceutical ingredients (APIs) during process optimization and pilot plant studies.
• Biochemical Research: Utilized in studies exploring enzyme inhibition and the biochemical pathways of steroid hormones.

Basic Information

Item	Details
Product Name	3β,11β,21-Trihydroxy-20-Oxo-5α-Pregnan-18-Oic Acid 18,11-Lactone
CAS No.	72101-51-0
Molecular Formula	C21H28O6
Molecular Weight	376.45 g/mol
Synonyms	18,11-Lactone of 3β,11β,21-Trihydroxy-20-oxo-5α-pregnan-18-oic Acid; 5α-Pregnan-18-oic acid, 3β,11β,21-trihydroxy-20-oxo-, 18,11-lactone; 3β,11β,21-Trihydroxy-20-oxo-5α-pregnan-18-oic acid γ-lactone; 18,11-Lactone of 3β,11β,21-Trihydroxy-20-oxopregnan-18-oic Acid; 11β,21-Dihydroxy-3,20-dioxo-5α-pregnan-18-oic acid 18,11-lactone (tautomeric form); Steroid Lactone Intermediate; Pregnane Lactone Derivative
EINECS	Contact for details

Quality Control

Our 3β,11β,21-Trihydroxy-20-Oxo-5α-Pregnan-18-Oic Acid 18,11-Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research applications. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product should be kept under inert atmosphere if long-term stability is required. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.