Description

N,1-Bis(Trimethylsilyl)-1H-Indole-3-Acetamide is a specialized organosilicon-protected indole derivative, serving as a critical synthetic intermediate in advanced organic synthesis. Its primary value lies in its role as a protected precursor for the indole-3-acetic acid moiety, enabling complex reactions under conditions where the free amine or carboxylic acid would be incompatible. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially those containing functionalized indole scaffolds.
• Agrochemical Research: Used in the development of novel plant growth regulators and pesticides that leverage indole-based chemistry.
• Peptide & Conjugate Synthesis: Acts as a protected synthon for incorporating indole-3-acetic acid derivatives into peptides or bioconjugates.
• Material Science Precursor: Potential starting material for creating functionalized organic molecules with silicon-containing groups for specialized materials.
• Academic & R&D Laboratories: Valuable reagent for methodological development in organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	N,1-Bis(Trimethylsilyl)-1H-Indole-3-Acetamide
CAS No.	72101-39-4
Molecular Formula	C18H30N2OSi2
Molecular Weight	346.62 g/mol
Synonyms	1H-Indole-3-acetamide, N,1-bis(trimethylsilyl)-; N-[2-(1,3-Bis(trimethylsilyl)-1H-indol-3-yl)ethyl]formamide (tautomer); 3-(Aminocarbonylmethyl)-1,3-bis(trimethylsilyl)indole; Bistrimethylsilyl Indole-3-acetamide; TMS-protected Indole-3-acetamide; N,1-Bis-TMS-indole-3-acetamide
EINECS	Contact for details

Quality Control

Our N,1-Bis(Trimethylsilyl)-1H-Indole-3-Acetamide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.