Description

[cis-Cyclohexanediylbis(Oxy)]Bis(Trimethylsilane) is a specialized organosilicon compound that serves as a versatile silylating agent and synthetic intermediate. Its core value lies in its ability to introduce protective trimethylsilyl (TMS) groups onto sensitive functional groups, particularly hydroxyls, thereby enabling complex synthetic sequences in advanced chemical manufacturing. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity reagents for protecting group chemistry and the synthesis of sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Used as a protecting agent for diols and polyols in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Production: Employed in the manufacture of advanced pesticides and herbicides where silylation is a key step in building the active molecule.
• Polymer & Material Science: Acts as a monomer or modifying agent in the synthesis of specialty silicones, siloxane-based polymers, and hybrid organic-inorganic materials.
• Analytical Chemistry: Utilized as a derivatization reagent in Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) to enhance the volatility and detectability of polar compounds.
• Organic Synthesis Reagent: A key reagent for the protection of hydroxyl groups in complex organic transformations, facilitating reactions that are otherwise incompatible with free -OH groups.
• Cross-coupling Reactions: May serve as a silicon-based coupling partner in transition metal-catalyzed cross-coupling reactions for C-Si bond formation.

Basic Information

Product Name	[cis-Cyclohexanediylbis(Oxy)]Bis(Trimethylsilane)
CAS No.	72088-20-1
Molecular Formula	C12H28O2Si2
Molecular Weight	260.52 g/mol
Synonyms	1,2-cis-Bis(trimethylsiloxy)cyclohexane; cis-1,2-Bis(trimethylsiloxy)cyclohexane; cis-Cyclohexane-1,2-diyl bis(trimethylsilyl) ether; Cyclohexane-1,2-diol, 1,2-bis(trimethylsilyl) ether, cis-; TMS ether of cis-1,2-Cyclohexanediol; cis-1,2-Cyclohexanediol bis(trimethylsilyl) ether; (1R,2S)-rel-1,2-Bis[(trimethylsilyl)oxy]cyclohexane; 1,2-cis-Bis-O-(trimethylsilyl)cyclohexane
EINECS	Contact for details

Quality Control

Our production of [cis-Cyclohexanediylbis(Oxy)]Bis(Trimethylsilane) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Every lot is characterized using advanced analytical techniques including GC, HPLC, and NMR to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.