Description

Fmoc-Met-Onp CAS NO 71989-29-2 is a specialized, protected amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with methionine residues. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected methionine derivative activated with an o-nitrophenyl (Onp) ester, it facilitates efficient and controlled peptide chain elongation.
• Therapeutic Peptide Production: A crucial intermediate in the synthesis of peptide-based pharmaceuticals targeting metabolic disorders, cancer, and infectious diseases.
• Research & Development: Used in academic and industrial R&D labs for exploring novel peptide structures, studying protein-protein interactions, and developing new synthetic methodologies.
• Bioconjugation: Serves as a reagent for introducing methionine residues into biomolecules for labeling, cross-linking, or functionalization purposes.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	Fmoc-Met-Onp
CAS No.	71989-29-2
Molecular Formula	C₂₅H₂₂N₂O₆S
Molecular Weight	478.52 g/mol
Synonyms	Fmoc-Methionine o-Nitrophenyl Ester; N-(9-Fluorenylmethoxycarbonyl)-L-methionine 4-Nitrophenyl Ester; Fmoc-L-methionine p-nitrophenyl ester; Fmoc-Met-ONp; (9H-Fluoren-9-yl)methyl N-[(2S)-1-[(4-nitrophenoxy)oxy]-1-oxo-3-(methylsulfanyl)propan-2-yl]carbamate; N-α-Fmoc-L-methionine p-nitrophenyl ester; Fmoc-Met-OPhNO2; Fmoc-Met-OPnp
EINECS	Contact for details

Quality Control

Our Fmoc-Met-Onp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.