Description

Fmoc-Gln-Onp CAS NO 71989-21-4 is a protected amino acid derivative, specifically an N-α-Fmoc protected glutamine side-chain activated with an o-nitrophenyl (Onp) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of glutamine residues. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the production of peptides, peptide hormones, and investigational APIs.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as an activated ester for the coupling of glutamine in Fmoc-based peptide assembly.
• Peptide Drug Intermediate: Synthesis of complex therapeutic peptides and peptide hormones requiring precise glutamine placement.
• Research & Development: A key reagent in academic and industrial R&D for novel peptide discovery and structure-activity relationship (SAR) studies.
• Bioconjugation: Potential use in the chemical modification of proteins or other biomolecules via its active ester group.
• Combinatorial Chemistry: Used in the generation of peptide libraries for high-throughput screening.
• Custom Peptide Service Providers: A staple raw material for CROs and CMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Gln-Onp
CAS No.	71989-21-4
Molecular Formula	C30H29N3O8
Molecular Weight	559.57 g/mol
Synonyms	Fmoc-Gln-ONp; N-α-Fmoc-L-glutamine 4-nitrophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-glutamine 4-nitrophenyl ester; Fmoc-L-glutaminol 4-nitrophenyl ester; Fmoc-Glutamine(ONp); (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-amino-5-oxopentanoic acid 4-nitrophenyl ester; Fmoc-Gln-ONp-OH; Fmoc-Gln(ONp)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Gln-Onp is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive peptide synthesis applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system supports compliance with cGMP guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.