Description

Fmoc-L-Glutamic Acid 5-tert-Butyl Ester is a crucial, high-purity protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring precise control over the glutamic acid side chain during the assembly of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs/CMOs developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating glutamic acid with a protected side chain carboxyl group, enabling the synthesis of complex peptide sequences.
• Pharmaceutical Research: In the development of novel peptide-based therapeutics, including hormones, enzyme inhibitors, and targeted drug conjugates.
• Bioconjugation & Labeling: For creating peptide tags, probes, or linkers where the glutamic acid moiety is used for subsequent conjugation after deprotection.
• Combinatorial Chemistry: Used in libraries for drug discovery to explore structure-activity relationships (SAR) of peptides containing glutamic acid.
• Biochemical Reagent Production: As a raw material for synthesizing specialized reagents, enzyme substrates, or standards for analytical purposes.

Basic Information

Product Name	Fmoc-L-Glutamic Acid 5-tert-Butyl Ester
CAS No.	71989-18-9
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-Glu(OtBu)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 5-tert-butyl ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanedioic acid 5-tert-butyl ester; Fmoc-L-Glu(OtBu)-OH; Nα-Fmoc-L-glutamic acid γ-tert-butyl ester; Fmoc-Glutamic acid 5-tert-butyl ester; Fmoc-Glu(OtBu)-OH (abbreviation); N-Fmoc-L-glutamic acid 5-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-L-Glutamic Acid 5-tert-Butyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-14.0° to -16.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.