Description

Butanedioic Acid, 2,3-Difluoro-, Dimethyl Ester, (2R,3R)-Rel- (9Ci) is a high-purity, chiral fluorinated succinate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the precise stereochemistry and fluorine substitution, which are essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including protease inhibitors and other fluorinated therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly protease inhibitors and other enzyme-targeted drugs.
• Agrochemical Research: Used in the development of new-generation, fluorinated pesticides and herbicides where the fluorine atoms enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a stereodefined building block in catalytic asymmetric reactions to construct complex molecules with high enantiomeric excess.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in fine chemical manufacturing.
• Material Science Research: Investigated as a monomer or modifier for introducing fluorine into polymers to alter surface properties and stability.
• Diagnostic Agent Synthesis: Potential use in the preparation of fluorinated probes and contrast agents for medical imaging.

Basic Information

Product Name	Butanedioic Acid, 2,3-Difluoro-, Dimethyl Ester, (2R,3R)-Rel- (9Ci)
CAS No.	71974-84-0
Molecular Formula	C6H8F2O4
Molecular Weight	182.12 g/mol
Synonyms	(2R,3R)-2,3-Difluorodimethyl succinate; Dimethyl (2R,3R)-2,3-difluorobutanedioate; (2R,3R)-Rel-2,3-Difluorobutanedioic Acid Dimethyl Ester; (R,R)-2,3-Difluorodimethyl succinate; Dimethyl (R,R)-2,3-difluorobutanedioate; 2,3-Difluorosuccinic Acid Dimethyl Ester, (2R,3R)-; (2R,3R)-2,3-Difluorosuccinic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our production of Butanedioic Acid, 2,3-Difluoro-, Dimethyl Ester, (2R,3R)-Rel- (9Ci) adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.