Description

α-Artemether is a potent, semi-synthetic derivative of artemisinin, a naturally occurring sesquiterpene lactone endoperoxide. This compound is a critical active pharmaceutical ingredient (API) valued for its high efficacy and rapid action against malaria parasites, particularly *Plasmodium falciparum*. It is essential for the pharmaceutical industry, specifically in the formulation of first-line artemisinin-based combination therapies (ACTs) for the global treatment of uncomplicated malaria.

Application

• Antimalarial Pharmaceutical Formulations: Primary use as the key API in artemisinin-based combination therapies (ACTs), such as co-formulations with Lumefantrine.
• Injectable Antimalarial Solutions: Used in the development of intramuscular or intravenous injections for severe malaria cases.
• Veterinary Parasiticides: Potential application in veterinary medicine for treating parasitic infections in animals.
• Pharmaceutical Research & Development: Serves as a reference standard and a key intermediate in the synthesis of novel antimalarial compounds and metabolic studies.
• Global Health Programs: Supplied for use in public health initiatives and procurement by organizations like the WHO for malaria-endemic regions.

Basic Information

Product Name	α-Artemether
CAS No.	71939-51-0
Molecular Formula	C16H26O5
Molecular Weight	298.37 g/mol
Synonyms	Artemether; Dihydroartemisinin Methyl Ether; Artemether (Alpha Isomer); (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin; Arteether (common misnomer); β-Arteether (related isomer); QHS; SM-224
EINECS	Contact for details

Quality Control

Our α-Artemether is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identity, assay, and impurity profile verification against relevant pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.