Description

2,2,2-Trifluoro-n-Methyl-n-4-Piperidinyl-Acetamide Monohydrochloride is a high-purity trifluoromethylated piperidine derivative, primarily utilized as a critical pharmaceutical intermediate. Its value lies in enabling the synthesis of advanced active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical industries, particularly those developing novel therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the trifluoromethyl group for improved efficacy.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the final synthetic steps of approved pharmaceutical products.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory to pilot and commercial production scales.
• Reference Standard: Used as an analytical standard for quality control and regulatory compliance in API production.

Basic Information

Product Name	2,2,2-Trifluoro-n-Methyl-n-4-Piperidinyl-Acetamide Monohydrochloride
CAS No.	71879-37-3
Molecular Formula	C9H16ClF3N2O
Molecular Weight	260.68 g/mol
Synonyms	N-Methyl-4-(2,2,2-trifluoroacetamido)piperidine Hydrochloride; 1-Methyl-4-(2,2,2-trifluoroacetamido)piperidinium Chloride; 4-(Trifluoroacetamido)-1-methylpiperidine Hydrochloride; 2,2,2-Trifluoro-N-methyl-N-(4-piperidinyl)acetamide Hydrochloride; TFMPA-HCl; N-Methyl-N-(piperidin-4-yl)-2,2,2-trifluoroacetamide Hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-Methyl-n-4-Piperidinyl-Acetamide Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.