Description

5-Chloro-2-Fluoro-3-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring chlorine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an essential intermediate for creating compounds with tailored biological activity and specific physical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and production of novel active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a building block for advanced materials, including liquid crystals, organic semiconductors, and functional polymers.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new reactions and creating libraries of compounds for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	5-Chloro-2-Fluoro-3-(Trifluoromethyl)Pyridine
CAS No.	71701-96-7
Molecular Formula	C6H2ClF4N
Molecular Weight	199.53 g/mol
Synonyms	2-Fluoro-5-chloro-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-5-chloro-2-fluoropyridine; 5-Chloro-2-fluoro-3-trifluoromethylpyridine; 5-Chloro-2-fluoro-alpha,alpha,α-trifluoro-3-picoline
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our standard grade for this intermediate typically meets a purity specification of ≥97% (by HPLC), with stringent control over related substances and residual solvents. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment. We can also support development projects with custom purity grades, including research and GMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.