Description

1,3-Dichloro-2-Trimethylsiloxy-1-Propene is a specialized organosilicon reagent featuring a reactive dichloroalkene moiety protected by a trimethylsilyl (TMS) group. This compound is valued for its role as a versatile synthetic building block in advanced organic synthesis, enabling the controlled introduction of functionalized propene units. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring functionalized allylic or propenyl structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where its reactive sites allow for the creation of specific bioactive motifs.
• Organosilicon Chemistry: Serves as a valuable reagent for introducing silicon-protected functional groups, facilitating subsequent transformations in multi-step synthetic routes.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials that incorporate silicon and halogen functionalities.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Academic & Industrial R&D: A critical tool for methodological development and exploring new reaction pathways in synthetic organic chemistry laboratories.

Basic Information

Product Name	1,3-Dichloro-2-Trimethylsiloxy-1-Propene
CAS No.	71482-67-2
Molecular Formula	C6H12Cl2OSi
Molecular Weight	199.15 g/mol
Synonyms	1,3-Dichloro-2-(trimethylsiloxy)-1-propene; 1-Propene, 1,3-dichloro-2-(trimethylsiloxy)-; 2-(Trimethylsiloxy)-1,3-dichloropropene; 1,3-Dichloro-2-trimethylsilyloxy-1-propene; (1,3-Dichloro-2-propenyloxy)trimethylsilane; TMS-protected 1,3-dichloro-2-hydroxypropene; Dichloro(trimethylsiloxy)propene
EINECS	Contact for details

Quality Control

Our 1,3-Dichloro-2-Trimethylsiloxy-1-Propene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.