Description

2-Propanone, 1-Chloro-3-(Trimethylsilyl)- is a specialized organosilicon compound that serves as a valuable building block in advanced organic synthesis. Its unique structure, combining a reactive chloroketone moiety with a silyl protecting group, makes it a versatile reagent for introducing functional complexity. This chemical is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular scaffolds and intermediates.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of complex bioactive molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced organic materials with tailored properties.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes for the controlled introduction of chloroketone and silyl ether functionalities.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed coupling reactions to form carbon-carbon bonds.
• Protecting Group Chemistry: The trimethylsilyl group can be used for the temporary protection of hydroxyl groups during complex syntheses.

Basic Information

Product Name	2-Propanone, 1-Chloro-3-(Trimethylsilyl)-
CAS No.	71482-65-0
Molecular Formula	C6H13ClOSi
Molecular Weight	164.70 g/mol
Synonyms	1-Chloro-3-(trimethylsilyl)acetone; 3-(Trimethylsilyl)-1-chloroacetone; 1-Chloro-3-(trimethylsilyl)-2-propanone; Chloro(trimethylsilyl)acetone; TMS-chloroacetone; Acetone, 1-chloro-3-(trimethylsilyl)-; (3-Chloro-1-oxopropan-2-yl)trimethylsilane
EINECS	Contact for details

Quality Control

Our production of 2-Propanone, 1-Chloro-3-(Trimethylsilyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.