Description

Z-Nva-Osu CAS NO 71447-85-3 is a high-purity, protected amino acid derivative, specifically N-α-(Z)-Norvaline N-hydroxysuccinimide ester. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of norvaline into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and biochemical tools. The Z (benzyloxycarbonyl) protecting group offers stability during synthesis, while the active ester (Osu) facilitates rapid and high-yield coupling reactions under mild conditions.

Application

• Peptide Synthesis: A key reagent for the controlled introduction of the non-proteinogenic amino acid norvaline into custom peptide sequences during Fmoc/t-Boc solid-phase or solution-phase synthesis.
• Pharmaceutical Research: Used in the development and production of peptide drug candidates, where norvaline is incorporated to modulate biological activity, stability, or pharmacokinetic properties.
• Bioconjugation: Employed to label proteins, antibodies, or other biomolecules with norvaline-containing tags or linkers for diagnostic assays or targeted drug delivery systems.
• Chemical Biology Probes: Integral to synthesizing specialized peptides used as probes to study enzyme mechanisms, protein-protein interactions, and cellular pathways.
• Agrochemical Development: Applied in the research of novel bioactive peptides for crop protection and agricultural science.
• Material Science: Used in the synthesis of peptide-based polymers and biomaterials where specific amino acid sequences are required to engineer desired properties.

Basic Information

Product Name	Z-Nva-Osu CAS NO 71447-85-3
CAS No.	71447-85-3
Molecular Formula	C₁₇H₂₂N₂O₆
Molecular Weight	350.37 g/mol
Synonyms	Z-Norvaline-OSu; N-α-Carbobenzoxy-L-norvaline N-succinimidyl ester; N-(Benzyloxycarbonyl)-L-norvaline N-hydroxysuccinimide ester; (S)-2-(((Benzyloxy)carbonyl)amino)pentanoic acid 2,5-dioxopyrrolidin-1-yl ester; Z-L-Nva-OSu; Z-Nva-OSu; Z-Nva-Osu ester; N-α-Z-L-Norvaline N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Z-Nva-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and IR for structural confirmation, and melting point determination. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Solubility	Soluble in DMF, DMSO, acetonitrile; slightly soluble in ethyl acetate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.