Description

4-{[5-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Aniline is a high-value, multifunctional aromatic amine intermediate featuring a pyridine core substituted with a trifluoromethyl group and an aniline moiety. This compound matters for its role as a critical building block in the synthesis of advanced agrochemicals and pharmaceuticals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by research and development chemists, process scale-up teams, and manufacturers in the agrochemical and pharmaceutical industries for creating novel active ingredients.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethylpyridine structure contributes to enhanced biological activity and environmental stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for the research and development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Ligand Synthesis: Serves as a starting material for creating specialized ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as charge-transport layers or photoactive components, due to its electron-deficient aromatic system.
• Dye and Pigment Intermediate: Functions as a versatile amine component in the synthesis of specialized dyes, pigments, and optical brighteners.

Basic Information

Product Name	4-{[5-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Aniline
CAS No.	71422-81-6
Molecular Formula	C12H9F3N2O
Molecular Weight	254.21 g/mol
Synonyms	4-[(5-Trifluoromethyl-2-pyridyl)oxy]aniline; 2-[(4-Aminophenoxy)methyl]-5-(trifluoromethyl)pyridine; 4-Aminophenyl 5-(trifluoromethyl)pyridin-2-yl ether; 4-(5-Trifluoromethylpyridin-2-yloxy)benzenamine; 4-(5-Trifluoromethyl-2-pyridinyloxy)aniline; 2-(4-Aminophenoxy)-5-(trifluoromethyl)pyridine; 71422-81-6; 4-(5-Trifluoromethylpyridin-2-yloxy)phenylamine
EINECS	Contact for details

Quality Control

Our 4-{[5-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and industrial synthesis. Certificates of Analysis (COA) with full traceability are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.