Description

Trimethylsilyl 3-(1H-Imidazol-4-Yl)-2-[(Trimethylsilyl)Amino]Propanoat E is a specialized organosilicon-protected derivative of histidine, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise control over reactivity and stability in sensitive chemical processes. It serves as a key protected intermediate in the synthesis of complex peptides, bioactive molecules, and novel pharmaceutical candidates, particularly where the imidazole and amino functionalities must be selectively manipulated.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of histidine-containing peptides and peptidomimetics for drug discovery and development.
• Peptide Chemistry: Used as a protected histidine analog in solid-phase and solution-phase peptide synthesis to prevent side reactions.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups provide temporary protection for amine and carboxylate functions, enabling multi-step synthetic sequences.
• Bioconjugation Research: Serves as a precursor for creating labeled or modified biomolecules for diagnostic and research applications.
• Organosilicon Chemistry: A valuable substrate for studying silylation reactions and the properties of silicon-nitrogen bonds.
• Agrochemical Synthesis: Potential intermediate in the development of novel active ingredients with specific biological activity.

Basic Information

Product Name	Trimethylsilyl 3-(1H-Imidazol-4-Yl)-2-[(Trimethylsilyl)Amino]Propanoat E
CAS No.	71241-10-6
Molecular Formula	C15H29N3O2Si2
Molecular Weight	339.58 g/mol
Synonyms	Bis(trimethylsilyl) Histidinate; Histidine Bis(trimethylsilyl) Ester; 2-[(Trimethylsilyl)amino]-3-(1H-imidazol-4-yl)propanoic Acid Trimethylsilyl Ester; Nα,O-Bis(trimethylsilyl)histidine; L-Histidine, Nα-(trimethylsilyl)-, trimethylsilyl ester; TMS-Histidine(TMS); Histidine TMS Derivative
EINECS	Contact for details

Quality Control

Our production of Trimethylsilyl 3-(1H-Imidazol-4-Yl)-2-[(Trimethylsilyl)Amino]Propanoat E adheres to strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for your critical research and production needs. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.