Description

(4R,5S,8S)-4α-Acetoxy-1,8-Bis(Acetoxymethyl)-4,4Aα,6,7,7Aβ,8,8Aβ,8Bα-Octahydro-8-Methylspiro[5H-Cyclopropa[3,4]Cyclohepta[1,2-C]Pyran-5,2'-Oxirane] is a complex, high-purity synthetic intermediate characterized by its intricate spirocyclic and polycyclic structure. This compound matters as a critical chiral building block for advanced pharmaceutical synthesis, enabling the construction of sophisticated molecular architectures. It is primarily needed by R&D and process chemistry teams in the pharmaceutical and fine chemical industries for developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, particularly in oncology, antiviral, and anti-inflammatory research.
• Advanced Organic Synthesis: Used as a sophisticated building block for constructing complex natural product analogs and other polycyclic molecular frameworks.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new stereoselective synthetic methodologies.
• Fine Chemical Production: Integral in the multi-step synthesis of high-value specialty chemicals requiring specific stereochemistry.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Academic & Industrial R&D: A valuable tool for chemical biology studies and exploring new chemical space in medicinal chemistry programs.

Basic Information

Product Name	(4R,5S,8S)-4α-Acetoxy-1,8-Bis(Acetoxymethyl)-4,4Aα,6,7,7Aβ,8,8Aβ,8Bα-Octahydro-8-Methylspiro[5H-Cyclopropa[3,4]Cyclohepta[1,2-C]Pyran-5,2'-Oxirane]
CAS No.	70447-97-1
Molecular Formula	C20H26O8
Molecular Weight	394.42 g/mol
Synonyms	4α-Acetoxy-1,8-bis(acetoxymethyl)-4,4aα,6,7,7aβ,8,8aβ,8bα-octahydro-8-methylspiro[5H-cyclopropa[3,4]cyclohepta[1,2-c]pyran-5,2'-oxirane]; Spiro[5H-cyclopropa[3,4]cyclohepta[1,2-c]pyran-5,2'-oxirane] derivative; CAS 70447-97-1; (4R,5S,8S)-rel-4α-Acetoxy-1,8-bis(acetoxymethyl)octahydro-8-methylspiro[5H-cyclopropa[3,4]cyclohepta[1,2-c]pyran-5,2'-oxirane]; Polycyclic Spiro Oxirane Intermediate
EINECS	Contact for details

Quality Control

Our (4R,5S,8S)-4α-Acetoxy-1,8-Bis(Acetoxymethyl)-4,4Aα,6,7,7Aβ,8,8Aβ,8Bα-Octahydro-8-Methylspiro[5H-Cyclopropa[3,4]Cyclohepta[1,2-C]Pyran-5,2'-Oxirane] is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and chiral analysis. Our quality commitment aligns with cGMP guidelines where applicable, ensuring reliability for critical pharmaceutical development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.