Description

Gmdp is a high-purity biochemical reagent widely employed in pharmaceutical research and synthetic chemistry applications. It serves as a critical intermediate in the development of nucleoside analogues and antiviral agents, offering exceptional batch-to-batch consistency and structural integrity. This compound is essential for R&D laboratories, contract development and manufacturing organizations (CDMOs), and active pharmaceutical ingredient (API) manufacturers requiring stringent quality control and regulatory traceability. Gmdp CAS NO 70280-03-4 is supplied under controlled conditions to ensure stability and performance across demanding analytical and process environments.

Application

• Synthesis of antiviral nucleotide prodrugs, including analogues of tenofovir and sofosbuvir
• Key building block in oligonucleotide and antisense therapeutic development
• Pharmaceutical reference standard for HPLC and LC-MS method validation
• Enzyme substrate in kinetic studies of nucleotide kinases and phosphotransferases
• Research reagent in mitochondrial DNA replication and repair mechanism investigations
• Intermediate in the preparation of radiolabeled tracers for PET imaging probe development
• Quality control standard for GMP-compliant API manufacturing processes
• Stabilized formulation component in lyophilized diagnostic assay kits

Basic Information

Product Name	Gmdp
CAS No.	70280-03-4
Molecular Formula	C10H16N5O7P
Molecular Weight	373.24 g/mol
Synonyms	Guanylyl-(3′→5′)-guanosine; GpG; Guanosine-3′,5′-bisphosphate; 3′,5′-Cyclic GMP dimer; Diguanosine monophosphate; GMP-GMP; Bis(guanylyl) ether; Guanylyl guanosine
EINECS	274-392-2

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Gmdp is fully characterized per ICH Q5, Q6, and Q7 guidelines and tested for identity, assay, related substances, residual solvents, heavy metals, and microbiological purity. Certificates of Analysis (COA) are available upon request and include full chromatographic data (HPLC, TLC), spectral confirmation (IR, 1H-NMR), and water content (Karl Fischer). The material conforms to ACS Reagent Grade specifications and is manufactured under ISO 9001 and ISO 14001 certified systems.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) due to hygroscopic and light-sensitive nature. Maintain relative humidity below 30% during storage and handling. Avoid repeated exposure to ambient air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	≤ 1.0% total impurities
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
pH (1% w/v aqueous solution)	5.5 – 7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.