Description

Cyclohexanecarboxylic Acid, 3-Hydroxy-, Methyl Ester, (1R,3S)- is a high-purity, single-enantiomer chiral building block of significant value in advanced organic synthesis. Its defined stereochemistry at the 1 and 3 positions makes it a critical intermediate for constructing complex molecules with specific three-dimensional architectures. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and specialty agrochemicals where stereochemical purity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of stereochemically defined active pharmaceutical ingredients (APIs), including potential candidates for cardiovascular, neurological, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure herbicides, fungicides, and plant growth regulators where biological activity is often stereospecific.
• Fine Chemical Production: Serves as a versatile building block for creating complex fragrances, flavors, and advanced materials that require precise chiral control.
• Asymmetric Catalysis Research: Employed as a standard or precursor in developing and testing new asymmetric synthetic methodologies and chiral catalysts.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process chemistry development in both university and corporate laboratory settings.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 3-Hydroxy-, Methyl Ester, (1R,3S)-
CAS No.	70144-91-1
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	(1R,3S)-Methyl 3-hydroxycyclohexanecarboxylate; (-)-Methyl (1R,3S)-3-hydroxycyclohexanecarboxylate; (1R,3S)-3-Hydroxycyclohexanecarboxylic acid methyl ester; Methyl (1R,3S)-3-hydroxycyclohexanecarboxylate; trans-(-)-Methyl 3-hydroxycyclohexanecarboxylate; (1R,3S)-3-Hydroxy-cyclohexanecarboxylic acid methyl ester; Chiral Methyl 3-hydroxycyclohexanecarboxylate
EINECS	Contact for details

Quality Control

Our Cyclohexanecarboxylic Acid, 3-Hydroxy-, Methyl Ester, (1R,3S)- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.