Description

2-[(1S)-2-Hydroxy-1-Methylethyl]-1H-Isoindole-1,3(2H)-Dione is a chiral, hydroxyl-functionalized isoindole-1,3-dione derivative, a valuable building block in asymmetric synthesis and pharmaceutical research. Its significance lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, enabling the development of high-purity active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific chiral centers into their target molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel therapeutic agents, particularly in developing central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Catalyst Ligand Precursor: Used to develop and synthesize novel chiral ligands for transition metal catalysis, enhancing enantioselectivity in chemical reactions.
• Agrochemical Research: Serves as a building block for creating chiral active ingredients in advanced herbicides, fungicides, and plant growth regulators.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products, flavors, fragrances, and specialty polymers requiring precise stereochemical control.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, exploring new asymmetric transformation pathways and reaction mechanisms.

Basic Information

Product Name	2-[(1S)-2-Hydroxy-1-Methylethyl]-1H-Isoindole-1,3(2H)-Dione
CAS No.	70058-19-4
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	(S)-2-(2-Hydroxypropyl)isoindoline-1,3-dione; (S)-N-(2-Hydroxypropyl)phthalimide; (1S)-1-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-propanol; L-N-(2-Hydroxypropyl)phthalimide; Phthalimide, N-[(1S)-2-hydroxy-1-methylethyl]-; 2-[(S)-2-Hydroxypropyl]isoindole-1,3-dione
EINECS	Contact for details

Quality Control

Our 2-[(1S)-2-Hydroxy-1-Methylethyl]-1H-Isoindole-1,3(2H)-Dione is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.