Description

(S)-n-Boc-Azetidine-2-Carboxylic Acid Methyl Ester is a high-purity, chiral building block essential for modern pharmaceutical synthesis. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other complex therapeutic agents. Pharmaceutical R&D departments and fine chemical manufacturers need it for constructing constrained peptidomimetics and other advanced molecular architectures where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel protease inhibitors and other small-molecule drugs.
• Peptidomimetic Research: Used to introduce the constrained (S)-azetidine-2-carboxylic acid scaffold into peptide backbones to enhance metabolic stability and bioavailability.
• API Development: Serves as a key building block in the research and process development of new Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Employed in medicinal chemistry for the stereoselective construction of complex molecules with defined chirality.
• Chemical Biology Probes: Utilized in the design and synthesis of specialized probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(S)-n-Boc-Azetidine-2-Carboxylic Acid Methyl Ester
CAS No.	107020-12-2
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid methyl ester; Methyl (S)-1-Boc-azetidine-2-carboxylate; (S)-1-Boc-2-carbomethoxyazetidine; (S)-Methyl 1-(tert-butoxycarbonyl)azetidine-2-carboxylate; (S)-1-N-Boc-azetidine-2-carboxylic acid methyl ester; (S)-Azetidine-2-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-Aze(2)-OMe (S-isomer)
EINECS	Contact for details

Quality Control

Our (S)-n-Boc-Azetidine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.