Description

Acetamide, n-[3-[(Trimethylsilyl)oxy]propyl]- is a specialized organosilicon derivative of acetamide, characterized by its trimethylsilyl-protected hydroxyl group. This functionalization makes it a valuable intermediate for introducing a polar, protected moiety into more complex molecular architectures, particularly in fine chemical synthesis. It is primarily sought by research and development chemists in the pharmaceutical and advanced materials sectors for constructing novel compounds where controlled hydrophilicity and silicon-based functionality are required.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, especially those requiring silicon-containing or polar side chains.
• Liquid Crystal & OLED Material Synthesis: Used in the development of advanced organic electronic materials, where the silyl ether group can act as a protective group or influence molecular alignment and properties.
• Surface Modification Agent: Employed in the functionalization of silica surfaces or other materials to alter surface energy, adhesion, or biocompatibility.
• Crosslinking Agent Precursor: Acts as a precursor for agents used in polymer chemistry to introduce amide and silyl ether linkages into polymer networks.
• Organic Synthesis Reagent: Utilized in multi-step synthetic routes as a protected form of 3-hydroxypropylamine, enabling selective reactions at other sites on the molecule.
• Agrochemical Intermediate: Applied in the research and development of novel herbicides, fungicides, or plant growth regulators with tailored properties.

Basic Information

Product Name	Acetamide, n-[3-[(Trimethylsilyl)oxy]propyl]-
CAS No.	151750-93-5
Molecular Formula	C8H19NO2Si
Molecular Weight	189.33 g/mol
Synonyms	N-[3-(Trimethylsilyloxy)propyl]acetamide; 3-[(Trimethylsilyl)oxy]-N-acetyl-1-propanamine; 1-[3-(Trimethylsilyloxy)propyl]acetamide; Acetamide, N-[3-(trimethylsiloxy)propyl]-; N-Acetyl-3-(trimethylsilyloxy)propylamine; (3-Acetamidopropoxy)trimethylsilane; TMS-protected N-(3-hydroxypropyl)acetamide
EINECS	Contact for details

Quality Control

Every batch of Acetamide, n-[3-[(Trimethylsilyl)oxy]propyl]- is produced and tested under strict quality management protocols to ensure consistency and purity for critical R&D and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as identity, assay, and impurity profiles. Our quality systems are designed to support development work from laboratory to pilot plant scale, with documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.