Description

1-(Trimethylsilyloxy)-2-Chlorocyclohexane is a versatile organosilicon reagent featuring both a silyl-protected hydroxyl group and a reactive chloro substituent on a cyclohexane ring. This bifunctional nature makes it a valuable intermediate in organic synthesis, particularly for the controlled introduction of cyclohexyl-derived structures. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials research and development teams seeking to build complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized cyclohexane motifs.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides where the chlorocyclohexyl unit is a critical structural component.
• Organosilicon Chemistry: Acts as a precursor for further silicon-based transformations, leveraging the trimethylsilyloxy group as a protective moiety or for subsequent functionalization.
• Polymer & Material Science: Employed in the development of specialty polymers, coatings, and silicone-based materials requiring specific cycloaliphatic properties.
• Cross-Coupling Reactions: The chloro group can participate in various metal-catalyzed coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Asymmetric Synthesis: The chiral center at the 2-position makes it a potential starting material or intermediate for the synthesis of enantiomerically pure compounds.

Basic Information

Product Name	1-(Trimethylsilyloxy)-2-Chlorocyclohexane
CAS No.	7742-88-3
Molecular Formula	C9H19ClOSi
Molecular Weight	206.78 g/mol
Synonyms	2-Chloro-1-(trimethylsilyloxy)cyclohexane; 2-Chlorocyclohexyloxytrimethylsilane; (2-Chlorocyclohexyloxy)trimethylsilane; 1-Chloro-2-(trimethylsiloxy)cyclohexane; Trimethyl((2-chlorocyclohexyl)oxy)silane; Cyclohexanol, 2-chloro-, 1-(trimethylsilyl) ether; O-Trimethylsilyl-2-chlorocyclohexanol
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyloxy)-2-Chlorocyclohexane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture ingress and degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.