Description

β-Estradiol 17-Hemisuccinate is a high-purity steroid derivative, specifically a hemisuccinate ester of the primary female sex hormone estradiol. This compound is a critical pharmaceutical intermediate, valued for its enhanced solubility and reactivity compared to the parent hormone, which facilitates its use in advanced drug synthesis. It is primarily required by manufacturers in the pharmaceutical and life science sectors for the development of hormone therapies, research reagents, and other specialized steroid-based products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced steroidal drugs and conjugated estrogens for hormone replacement therapy (HRT).
• Research & Development: Used as a reference standard and biochemical tool in endocrinology and oncology research to study estrogen receptor activity.
• Prodrug Synthesis: Utilized to create prodrug forms of estradiol with improved bioavailability and targeted delivery profiles.
• Bioconjugation: Serves as a starting material for attaching estradiol to carriers, labels, or other molecules for diagnostic and therapeutic applications.
• Veterinary Medicine: Employed in the formulation of hormonal treatments for animals.

Basic Information

Product Name	β-Estradiol 17-Hemisuccinate
CAS No.	7698-93-3
Molecular Formula	C22H28O6
Molecular Weight	388.46 g/mol
Synonyms	Estradiol 17-Hemisuccinate; Estradiol Hemisuccinate; 17β-Estradiol 17-Hemisuccinate; Oestradiol Hemisuccinate; E2-17-HS; NSC 17591; (17β)-Estra-1,3,5(10)-triene-3,17-diol 17-hemisuccinate; 3,17β-Dihydroxyestra-1,3,5(10)-trien-17-yl hydrogen succinate
EINECS	Contact for details

Quality Control

Our β-Estradiol 17-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets stringent specifications for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.