Description

2-Chloro-1,5-Naphthyridine is a versatile and high-value halogenated heterocyclic building block essential for advanced organic synthesis. Its core value lies in its reactivity as a key intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce the 1,5-naphthyridine scaffold into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other biologically active molecules containing the 1,5-naphthyridine core.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the chloro substituent allows for further functionalization.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized ligands used in coordination chemistry and catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or luminescent compounds, due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination, enabling rapid diversification of the heterocyclic structure.
• Nucleophilic Aromatic Substitution: The chlorine atom is amenable to displacement by various nucleophiles, facilitating the introduction of amines, alkoxides, and other functional groups.

Basic Information

Product Name	2-Chloro-1,5-Naphthyridine
CAS No.	7689-62-5
Molecular Formula	C8H5ClN2
Molecular Weight	164.59 g/mol
Synonyms	2-Chloro-1,5-naphthyridine; 1,5-Naphthyridine, 2-chloro-; 2-Chloro-1,5-diazanaphthalene; 2-Chloro[1,5]naphthyridine; 2-Chloro-1,5-naphthyridine (ACI); NSC 406083
EINECS	Contact for details

Quality Control

Our 2-Chloro-1,5-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.