Description

Z-Glu(Otbu)-Onp is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-carbobenzoxy-L-glutamic acid α-tert-butyl ester. This compound serves as a crucial building block in peptide synthesis, offering controlled reactivity for the selective formation of peptide bonds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutic peptides and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient incorporation of glutamic acid with side-chain protection into peptide chains.
• Solution-Phase Peptide Synthesis: Used in the synthesis of peptide fragments and small peptides where tert-butyl and Cbz protecting groups are required.
• Pharmaceutical Intermediate: A key precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Employed for coupling peptides to other molecules, such as dyes, polymers, or carrier proteins, in bioconjugate chemistry.
• Organic Synthesis: Serves as a versatile reagent for introducing the glutamyl moiety into complex organic molecules under mild conditions.
• Biochemical Research: Used in studies involving enzyme substrates, receptor ligands, and the structure-activity relationships (SAR) of peptides.

Basic Information

Product Name	Z-Glu(Otbu)-Onp
CAS No.	7670-08-8
Molecular Formula	C₂₂H₂₄N₂O₈
Molecular Weight	444.44 g/mol
Synonyms	N-Carbobenzoxy-L-glutamic acid α-tert-butyl ester p-nitrophenyl ester; Z-L-Glutamic acid α-tert-butyl ester 4-nitrophenyl ester; Cbz-Glu(OtBu)-ONp; Nα-Cbz-L-glutamic acid 1-tert-butyl ester 5-(4-nitrophenyl) ester; Z-Glu(OtBu)-ONp; Z-Glutamic acid α-tert-butyl ester p-nitrophenyl ester; (S)-5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid; N-[(Benzyloxy)carbonyl]-L-glutamic acid 1-(1,1-dimethylethyl) ester 5-(4-nitrophenyl) ester
EINECS	Contact for details

Quality Control

Our Z-Glu(Otbu)-Onp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.