Description

Ethyl Iododifluoroacetate is a versatile fluorinated building block and reagent essential for introducing the difluoroacetate moiety into target molecules. Its high reactivity, particularly the iodine atom, makes it a critical intermediate for synthesizing complex fluorinated compounds in advanced research and development. This product is primarily sought by the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, crop protection, and specialty polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging fluorine's ability to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of novel fluorinated pesticides and herbicides, where the difluoroacetate group can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty fluoropolymers and advanced materials with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and nucleophilic substitutions to construct complex molecular architectures in academic and industrial R&D laboratories.
• Ligand and Catalyst Development: Useful for preparing fluorinated ligands for catalysis and molecular recognition studies.

Basic Information

Product Name	Ethyl Iododifluoroacetate
CAS No.	7648-30-8
Molecular Formula	C4H5F2IO2
Molecular Weight	257.98 g/mol
Synonyms	Ethyl 2-Iodo-2,2-difluoroacetate; Iododifluoroacetic Acid Ethyl Ester; Difluoro(iodo)acetic Acid Ethyl Ester; Ethyl Difluoro(iodo)acetate; 2,2-Difluoro-2-iodoacetic Acid Ethyl Ester; Ethyl α,α-Difluoro-α-iodoacetate; Acetic acid, 2,2-difluoro-2-iodo-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl Iododifluoroacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by our global customer base in research and industrial chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C to maximize shelf life and stability. Keep container tightly sealed when not in use to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.