Description

n-[(Benzyloxy)Carbonyl]-L-Leucine 2,4,5-Trichlorophenyl Ester is a specialized, high-purity amino acid derivative used as a key building block in peptide synthesis. This compound is valued for its role as an activated ester, facilitating efficient and selective amide bond formation under mild conditions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the controlled, stepwise assembly of peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: Employed in classical coupling reactions for constructing specific peptide sequences in solution.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex peptide-based drug candidates and therapeutic agents.
• Bioconjugation: Used to attach peptide motifs or labels to other biomolecules, polymers, or surfaces for research and diagnostic applications.
• Chemical Biology Research: A valuable tool for probing protein-protein interactions and studying enzyme mechanisms through the introduction of modified leucine residues.
• Process Development: Utilized in scaling up synthetic routes for peptide APIs under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Leucine 2,4,5-Trichlorophenyl Ester
CAS No.	7646-49-3
Molecular Formula	C20H20Cl3NO4
Molecular Weight	444.73 g/mol
Synonyms	Z-L-Leu-OTcp; Z-Leu-OTcp; Cbz-L-Leucine 2,4,5-Trichlorophenyl Ester; N-Carbobenzoxy-L-leucine 2,4,5-trichlorophenyl ester; Nα-Cbz-L-leucine 2,4,5-trichlorophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic acid 2,4,5-trichlorophenyl ester; L-Leucine, N-[(phenylmethoxy)carbonyl]-, 2,4,5-trichlorophenyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, chiral purity, and related substances are available upon request. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.