Description

(+)-Menthyl Chloroformate CAS NO 7635-54-3 is a chiral chloroformate ester derived from menthol, serving as a versatile chiral auxiliary and derivatizing agent in organic synthesis. Its primary value lies in its ability to introduce the bulky, chiral menthyl group, which is crucial for the resolution of racemic mixtures and the synthesis of enantiomerically pure compounds. This high-purity intermediate is essential for research and production in the pharmaceutical and fine chemical industries, where stereochemical control is paramount.

Application

• Chiral Resolution Agent: Used for the separation of enantiomers of amines, alcohols, and carboxylic acids via diastereomeric derivative formation.
• Pharmaceutical Intermediate: A key building block in the asymmetric synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Peptide Synthesis: Employed as a protecting group for amino acids or as a coupling reagent in peptide chemistry.
• Catalyst and Ligand Preparation: Used in the synthesis of chiral catalysts and ligands for asymmetric catalysis.
• Analytical Chemistry: Serves as a derivatization reagent for chiral analysis by techniques like gas chromatography (GC) or high-performance liquid chromatography (HPLC).
• Fine Chemical Synthesis: Utilized in the production of specialty chemicals, flavors, and fragrances where enantiopurity is critical.

Basic Information

Product Name	(+)-Menthyl Chloroformate
CAS No.	7635-54-3
Molecular Formula	C11H19ClO2
Molecular Weight	218.72 g/mol
Synonyms	(1R,2S,5R)-Menthyl chloroformate; L-Menthyl chloroformate; (-)-Menthyl chloroformate; (1R)-(-)-Menthyl chloroformate; Chloroformic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester; Menthyl chlorocarbonate; NSC 403811; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl chloroformate
EINECS	231-577-5

Quality Control

Our (+)-Menthyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC or GC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]20/D	-70° to -75° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.