Description

D-(+)-Malic Acid Diethyl Ester is a high-purity chiral ester derivative of malic acid, serving as a critical building block in asymmetric synthesis. Its value lies in providing a versatile, enantiomerically pure intermediate for constructing complex molecules with defined stereochemistry. This compound is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise chiral control is paramount for product efficacy and safety.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs), particularly in antiviral and cardiovascular drug candidates.
• Asymmetric Synthesis: Employed as a precursor for chiral ligands, auxiliaries, and catalysts used in stereoselective reactions.
• Agrochemical Synthesis: Used in the manufacture of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Flavor and Fragrance Industry: Serves as a starting material for synthesizing specific ester-based flavor compounds and aroma chemicals.
• Fine Chemical Production: A versatile intermediate for creating specialty chemicals, including complex esters and functionalized organic molecules.
• Academic and R&D: Utilized in research laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	D-(+)-Malic Acid Diethyl Ester
CAS No.	7554-28-1
Molecular Formula	C8H14O5
Molecular Weight	190.19 g/mol
Synonyms	Diethyl D-Malate; (R)-(-)-Diethyl Malate; Diethyl (R)-(-)-Hydroxysuccinate; D-(-)-Malic Acid Diethyl Ester; Diethyl (2R)-2-Hydroxybutanedioate; (R)-Diethyl 2-Hydroxysuccinate; Ethyl D-Malate; L 01759
EINECS	231-440-2

Quality Control

Our D-(+)-Malic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Specific Rotation [α]20/D	-7.5° to -9.0° (c=1 in ethanol)
Refractive Index n20/D	1.430 - 1.435
Density (20°C)	1.120 - 1.135 g/mL
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.