Description

Boc-Phe-Onp is a protected amino acid derivative, specifically N-tert-Butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester. This compound serves as a crucial activated ester intermediate in peptide synthesis, enabling the efficient and selective formation of peptide bonds. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for the development of novel peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential addition of phenylalanine residues.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for the synthesis of specific peptide sequences.
• Pharmaceutical Intermediate: For the research and production of therapeutic peptides targeting various diseases.
• Bioconjugation: Facilitating the attachment of peptide motifs to other molecules, polymers, or surfaces.
• Academic & Industrial R&D: A fundamental reagent in medicinal chemistry and chemical biology research for exploring structure-activity relationships.
• Production of Custom Peptides: Enables contract research and manufacturing organizations (CROs/CMOs) to produce high-purity, bespoke peptides for clients.

Basic Information

Product Name	Boc-Phe-Onp
CAS No.	7535-56-0
Molecular Formula	C₂₀H₂₂N₂O₆
Molecular Weight	386.40 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-phenylalanine 4-nitrophenyl ester; Boc-L-phenylalanine 4-nitrophenyl ester; Boc-Phe-ONp; (S)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid 4-nitrophenyl ester; N-Boc-L-phenylalanine p-nitrophenyl ester; Nα-Boc-L-phenylalanine 4-nitrophenyl ester; BOC-PHE-ONP; tert-Butyloxycarbonylphenylalanine paranitrophenyl ester
EINECS	Contact for details

Quality Control

Our Boc-Phe-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry atmosphere to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Melting Point	118°C - 122°C
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.