Description

Dimethyl trans-(+)-1,2-Cyclobutanedicarboxylate is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its rigid, strained cyclobutane ring and defined stereochemistry make it a versatile precursor for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including antiviral agents, enzyme inhibitors, and other bioactive compounds.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to introduce the cyclobutane moiety with high enantiomeric purity.
• Ligand and Catalyst Development: Serves as a backbone for creating novel chiral ligands and organocatalysts used in stereoselective transformations.
• Material Science Research: Employed in the development of polymers and advanced materials with specific structural properties derived from the strained ring system.
• Academic and R&D Laboratories: A valuable reagent for methodological studies and exploring new synthetic routes in organic chemistry.
• Fine Chemical Production: Used in the multi-step synthesis of fragrances, agrochemicals, and other high-value specialty chemicals.

Basic Information

Product Name	Dimethyl trans-(+)-1,2-Cyclobutanedicarboxylate
CAS No.	7371-67-7
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	(1R,2R)-1,2-Cyclobutanedicarboxylic Acid Dimethyl Ester; (+)-trans-1,2-Bis(methoxycarbonyl)cyclobutane; Dimethyl (1R,2R)-1,2-Cyclobutanedicarboxylate; trans-(+)-Dimethyl 1,2-Cyclobutanedicarboxylate; (R,R)-Dimethyl Cyclobutane-1,2-dicarboxylate; trans-1,2-Cyclobutanedicarboxylic Acid Dimethyl Ester; DM-CBD
EINECS	Contact for details

Quality Control

Our Dimethyl trans-(+)-1,2-Cyclobutanedicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.