Description

n-(Trimethylsilyl)-L-Phenylalanine Trimethylsilyl Ester is a key organosilicon-protected derivative of the essential amino acid L-phenylalanine. This compound is critically important as a versatile synthetic intermediate, offering enhanced solubility and stability for advanced peptide coupling and organic synthesis. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers for the production of complex peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis Intermediate: Used as a protected amino acid building block in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Research: Serves as a key precursor in the development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Facilitates the site-specific modification of peptides and proteins for drug delivery and diagnostic applications.
• Organic Synthesis Reagent: Employed in the synthesis of non-natural amino acids and complex organic molecules requiring silyl protection.
• Protecting Group Strategy: The trimethylsilyl groups protect the carboxylic acid and amine functionalities, allowing selective reactions at other sites.

Basic Information

Product Name	n-(Trimethylsilyl)-L-Phenylalanine Trimethylsilyl Ester
CAS No.	7364-51-4
Molecular Formula	C15H27NO2Si2
Molecular Weight	309.55 g/mol
Synonyms	L-Phenylalanine, N-(trimethylsilyl)-, trimethylsilyl ester; N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester; N-TMS-L-Phenylalanine TMS Ester; N,O-Bis(trimethylsilyl)-L-phenylalanine; (S)-2-((Trimethylsilyl)amino)-3-phenylpropanoic acid trimethylsilyl ester; N-Trimethylsilyl-L-phenylalanine trimethylsilyl ester; 7364-51-4; Amino acid silyl ester
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-L-Phenylalanine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for research and synthesis applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.