Description

N,S-Bis(Trimethylsilyl)-L-Cysteine Trimethylsilyl Ester is a fully silylated derivative of the amino acid L-cysteine, designed to enhance reactivity and stability in demanding synthetic environments. This compound is a critical reagent for introducing protected cysteine moieties and for derivatization in analytical chemistry, offering superior handling characteristics compared to the free amino acid. It is primarily utilized by researchers and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors for peptide synthesis, proteomics, and the development of novel chemical entities.

Application

• Peptide Synthesis: Acts as a key protected cysteine building block for solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Analytical Derivatization: Used to derivative amino acids, including cysteine, for Gas Chromatography (GC) and Mass Spectrometry (MS) analysis, improving volatility and detection.
• Proteomics Research: Serves as a reagent in the study of protein structure, function, and post-translational modifications.
• Chemical Intermediate: Functions as a versatile synthon in organic synthesis for creating complex molecules, including heterocycles and functionalized materials.
• Bioconjugation: Facilitates the site-specific modification of proteins and other biomolecules through its reactive silyl-protected thiol group.
• Stability Studies: Employed in pharmaceutical development to create stable analogs of cysteine-containing compounds for formulation and delivery research.

Basic Information

Product Name	N,S-Bis(Trimethylsilyl)-L-Cysteine Trimethylsilyl Ester
CAS No.	7364-50-3
Molecular Formula	C12H29NO2SSi3
Molecular Weight	335.68 g/mol
Synonyms	L-Cysteine, N,S-bis(trimethylsilyl)-, trimethylsilyl ester; Trimethylsilyl N-[trimethylsilyl)thio]-L-cysteine trimethylsilyl ester; N,O,S-Tris(trimethylsilyl)-L-cysteine; Silylated L-Cysteine; TMS-Cysteine; BSA Derivative of L-Cysteine; N-(Trimethylsilyl)-S-(trimethylsilyl)-L-cysteine trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our N,S-Bis(Trimethylsilyl)-L-Cysteine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.