Description

1-(Trimethylsilyl)Pyrrolidine-2α-Carboxylic Acid (Trimethylsilyl) Ester is a specialized organosilicon-protected amino acid derivative, serving as a crucial building block in advanced organic synthesis. Its value lies in providing a dual-protected proline analog, offering enhanced stability and reactivity control for complex molecule construction. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing novel peptide-based therapeutics and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex, proline-containing drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used in the design and production of peptide analogs and mimetics with improved metabolic stability and bioavailability.
• Agrochemical Research: Serves as a precursor in the development of novel pesticides and herbicides with specific chiral properties.
• Asymmetric Catalysis: Employed as a chiral auxiliary or ligand precursor in stereoselective synthesis and catalytic processes.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Production: Used in the multi-step synthesis of high-value, specialty chemicals and flavors/fragrances.

Basic Information

Product Name	1-(Trimethylsilyl)Pyrrolidine-2α-Carboxylic Acid (Trimethylsilyl) Ester
CAS No.	7364-47-8
Molecular Formula	C11H23NO2Si2
Molecular Weight	257.48 g/mol
Synonyms	1-(Trimethylsilyl)-2-pyrrolidinecarboxylic Acid Trimethylsilyl Ester; (S)-1-(Trimethylsilyl)pyrrolidine-2-carboxylic Acid Trimethylsilyl Ester; L-Proline, 1-(trimethylsilyl)-, bis(trimethylsilyl) ester; Proline, N-(trimethylsilyl)-, bis(trimethylsilyl) ester; N-Trimethylsilyl-L-proline bis(trimethylsilyl) ester; N-TMS-L-Proline bis-TMS ester; 7364-47-8; 1-(TMS)-Proline bis(TMS) ester
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyl)Pyrrolidine-2α-Carboxylic Acid (Trimethylsilyl) Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.