Description

n-Trimethylsilyl-L-Leucine Trimethylsilyl Ester is a high-purity, organosilicon-protected derivative of the essential amino acid L-leucine, widely used as a key synthetic intermediate and protecting group reagent. This compound is critical for ensuring high yields and stereochemical integrity in complex peptide and small molecule synthesis, particularly where moisture-sensitive reactions are required. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and advanced organic chemistry sectors for developing novel therapeutic agents and fine chemicals.

Application

• Peptide Synthesis: Serves as a crucial protected amino acid building block for solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and prodrugs that incorporate leucine or require silyl protection strategies.
• Derivatization Agent: Employed in gas chromatography (GC) and mass spectrometry (MS) for the derivatization of amino acids and other carboxylic acids to improve volatility and detection.
• Organic Synthesis: Acts as a versatile reagent for introducing the leucine moiety under anhydrous conditions in the synthesis of complex natural products and specialty chemicals.
• Bioconjugation & Labeling: Facilitates the site-specific modification of biomolecules in research applications for drug delivery and diagnostic probe development.

Basic Information

Product Name	n-Trimethylsilyl-L-Leucine Trimethylsilyl Ester
CAS No.	7364-46-7
Molecular Formula	C15H35NO2Si2
Molecular Weight	317.62 g/mol
Synonyms	L-Leucine, N-(trimethylsilyl)-, trimethylsilyl ester; N,O-Bis(trimethylsilyl)-L-leucine; N-Trimethylsilyl-L-leucine TMS ester; (S)-2-((Trimethylsilyl)amino)-4-methylpentanoic acid trimethylsilyl ester; TMS-Leucine-OTMS; N-TMS-L-Leucine TMS Ester; Leucine, N-trimethylsilyl-, trimethylsilyl ester, L-
EINECS	Contact for details

Quality Control

Our n-Trimethylsilyl-L-Leucine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Keep away from heat and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Rotation [α]20/D	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.