Description

n-(Trimethylsilyl)-L-Norvaline (Trimethylsilyl) Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound is specifically designed to provide a stable, silylated intermediate that facilitates complex peptide coupling and chiral synthesis with high selectivity and yield. It is a critical building block for researchers and manufacturers in pharmaceutical development, agrochemical research, and specialty chemical production who require reliable, high-quality chiral synthons.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce the L-norvaline residue while preventing racemization.
• Agrochemical Research: Serves as a chiral precursor in the development of herbicides, fungicides, and other bioactive compounds with specific stereochemical requirements.
• Asymmetric Synthesis: Employed as a building block in catalytic asymmetric reactions to construct complex molecules with defined chirality.
• Bioconjugation & Labeling: Useful in modifying biomolecules or creating labeled compounds for diagnostic and research purposes.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	n-(Trimethylsilyl)-L-Norvaline (Trimethylsilyl) Ester
CAS No.	7364-45-6
Molecular Formula	C11H25NO2Si2
Molecular Weight	259.50 g/mol
Synonyms	L-Norvaline, N-(trimethylsilyl)-, bis(trimethylsilyl) ester; N,O-Bis(trimethylsilyl)-L-norvaline; (S)-2-((Trimethylsilyl)amino)-N-(trimethylsilyloxy)pentanamide; N-Trimethylsilyl-L-norvaline trimethylsilyl ester; L-Norvaline, N-(trimethylsilyl)-, trimethylsilyl ester; Protected L-Norvaline derivative; TMS-L-Norvaline-OTMS
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-L-Norvaline (Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.