Description

n-(Trimethylsilyl)-L-Valine (Trimethylsilyl) Ester is a specialized silylated derivative of the essential amino acid L-valine, designed for advanced synthetic applications. This compound is crucial for protecting sensitive functional groups and facilitating challenging peptide coupling reactions under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel peptides, peptidomimetics, and other complex organic molecules.

Application

• Peptide Synthesis: Acts as a key protected amino acid building block for solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for complex peptide-based therapeutics.
• Chemical Derivatization: Employed to temporarily mask the carboxylic acid group of L-valine, enabling selective reactions at other sites on the molecule.
• Process Chemistry: Facilitates scalable synthetic routes in process development by improving solubility and reaction yields in non-polar solvents.
• Bioconjugation: Serves as a reagent in the modification of biomolecules where a protected valine moiety is required.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and medicinal chemistry research.

Basic Information

Product Name	n-(Trimethylsilyl)-L-Valine (Trimethylsilyl) Ester
CAS No.	7364-44-5
Molecular Formula	C11H25NO2Si2
Molecular Weight	259.50 g/mol
Synonyms	L-Valine, N-(trimethylsilyl)-, bis(trimethylsilyl) ester; N,O-Bis(trimethylsilyl)-L-valine; Valine, N-(trimethylsilyl)-, bis(trimethylsilyl) ester; N-(Trimethylsilyl)valine bis(trimethylsilyl) ester; N-TMS-L-valine TMS ester; Bis(trimethylsilyl) N-trimethylsilyl-L-valinate
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-L-Valine (Trimethylsilyl) Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and assay determination, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.