Description

L-Aspartic Acid Benzyl Ester is a protected derivative of the amino acid L-aspartic acid, where the carboxylic acid side chain is esterified with a benzyl group. This modification is crucial in organic synthesis and peptide chemistry, as it masks the reactive acid functionality, allowing for selective reactions at other sites of the molecule. It serves as a key chiral building block and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly in the synthesis of peptides, peptidomimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected aspartic acid residue to prevent side reactions.
• Bioconjugation & Linker Chemistry: Serves as a precursor for constructing specialized linkers and spacer arms in antibody-drug conjugates (ADCs) and bioconjugates.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in asymmetric catalytic reactions to induce chirality in target molecules.
• Biochemical Research: Utilized in academic and industrial R&D for studying enzyme mechanisms, protein interactions, and metabolic pathways.
• Fine Chemical Production: Acts as a building block for manufacturing specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	L-Aspartic Acid Benzyl Ester
CAS No.	7362-93-8
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	H-Asp(OBzl)-OH; (S)-2-Amino-4-(benzyloxy)-4-oxobutanoic acid; L-Aspartic acid 4-benzyl ester; Benzyl L-aspartate; Aspartic acid benzyl ester; (S)-2-Aminosuccinic acid 4-benzyl ester; Fmoc-Asp(OBzl)-OH (when N-Fmoc protected); Bzl-Asp-OH
EINECS	230-904-9

Quality Control

Our L-Aspartic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (HPLC), identity confirmation (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability, consistency, and compliance with your research or production protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to minimize exposure to atmospheric moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	-20.0° to -24.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.